Table 1. Changes in intrinsic membrane properties of PCs by prolonged application of low and high dose Aβ42.

	Aβ42 (1 nM, n = 8)		Aβ42 (500 nM, n = 7)
	ctrl	Aβ	ctrl	Aβ
Resting membrane potential (mV)	−64.6±2.1	−61.5±2.4	−66.7±2.5	−66.0±2.8
AP analysis
Threshold (mV)	−49.4±1.3	−44.1±1.9*	−49.1±1.0	−52.5±1.0*
AP_amplitude (mV)	62.5±9.8	55.4±9.2	68.9±5.8	60.7±11.2
AP_half_duration (ms)	2.1±0.3	2.3±0.4	2.2±0.1	1.8±0.4
AP_rise_rate (mV/ms)	39.4±6.1	35.9±6.6	45.1±4.6	38.8±8.0
AHP Analysis
Max_fall_rate (mV/ms)	−11.4±2.8	−17.0±2.1$	−21.1±5.0	−20.0±5.0$
Max_rise_rate (mV/ms)	32.2±6.1	47.3±4.6$	51.5±9.2	47.8±9.1$

^* p<0.05.

^$Net change (Aβ - ctrl) is statistically significant (p<0.05; see Fig. 7D).

Note 1: During application of Aβ, AP and AHP were recorded while clamping membrane potential at the same level as control.

Note 2: Data are mean±SE. (For the data of mean±SD, please see Table S2).