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Sequence diversity of 637 TRAIL-receptor binding scFv. VH germline gene segment utilization is shown for the panel of 234 TRAIL-R1 specific scFv (blue bars), 269 TRAIL-R2 specific scFv (red bars) and 134 TRAIL-R1/-R2 cross-reactive scFv (yellow bars). The frequency of VH germline utilization is expressed as a percentage of the total for each panel of scFv.
