Table 1.
Entry | Aldehyde | Product | Yieldb (%) |
---|---|---|---|
1 |
1b E:Z= 74:26 |
86 | |
2 |
1c E:Z= 64:36 |
72 | |
3 |
1dE:Z= 75:25 |
71 | |
4 |
1e E:Z= 55:45 |
76 | |
5 |
1f E:Z= 100:0 |
78 |
All reactions were performed using 1 equiv of aldehyde and 3 equiv of tBuONa in DMF for 2–12 h.
Isolated yield (mixture of E and Z) refers to aldehyde and the E/Z ratios were determined by 1H NMR.