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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Dermatol Clin. 2010 Jan;28(1):93–105. doi: 10.1016/j.det.2009.10.011

Figure 6.

Figure 6

Demonstration of genetic linkage between the dominant dystrophic epidermolysis bullosa phenotype and a type VII collagen allele in a family with 20 affected and 22 unaffected living individuals in four generations. The type VII collagen allele was tracked by inheritance of a PvuII polymorphic marker. Note that the disease allele tracks with the B-allele of COL7A1. (Adapted from Ryynänen M, Knowlton RG, Parente MG, et al. Human type VII collagen: genetic linkage of the gene (COL7A1) on chromosome 3 to dominant dystrophic epidermolysis bullosa. Am J Hum Genet 1991; 49: 797–803., with permission).