Volume	$\mathit{Vol}={\displaystyle \sum _{\forall x,\forall y,\forall z}{F}_{\mathit{ROI}}(x,y,z)\cdot p^2\cdot t}$	(1)
Surface	$\mathit{Surf}={\displaystyle \sum _{\forall x,\forall y,\forall z}{S}_{\mathit{ROI}}(x,y,z)\cdot p\cdot t}$	(2)
Compactness	$\mathit{Comp}=\frac{{\mathit{Surf}}^2}{\mathit{Vol}}$	(3)
NRL mean	${\mu }_{\mathit{NRL}}=\frac{1}{N}{\displaystyle \sum _{j=1\dots N}{r}_j}$	(4)
Sphericity	$\mathit{Spher}=\frac{{\mu }_{\mathit{NRL}}}{{\sigma }_{\mathit{NRL}}}$	(5)
NRL entropy	$E_{\mathit{NRL}}=-{\displaystyle \sum _{j=1\dots H}{\mathit{prob}}_j{\text{log}}_2({\mathit{prob}}_j)}$	(6)
Where	$\text{Pr}{\mathit{ob}}_j=\frac{r_j}{{\displaystyle \sum r_j}}$
NRL ratio	$R_{\mathit{NRL}}=\frac{1}{N\cdot {\mu }_{\mathit{NRL}}}{\displaystyle \sum _{j=1\dots N}(r_j-{\mu }_{\mathit{NRL}}):r_j>{\mu }_{\mathit{NRL}}}$	(7)
Roughness	$\mathit{Rough}=\frac{\sqrt[4]{\frac{1}{N}{\displaystyle \sum _{j=1\dots N}{(r_j-{\mu }_{\mathit{NRL}})}^4}}-\sqrt{\frac{1}{N}{\displaystyle \sum _{j=1\dots N}{(r_j-{\mu }_{\mathit{NRL}})}^2}}}{{\mu }_{\mathit{NRL}}}$	(8)

Where F_ROI is the pixel number in the ROI,

S_ROI is the pixel number along the boundary of the ROI,

σ_NRL is the standard deviation of NRL,