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. Author manuscript; available in PMC: 2010 Dec 14.
Published in final edited form as: Biochemistry. 2009 Dec 15;48(49):11766–11772. doi: 10.1021/bi9014874

FIG 8. Logo representation of the aligned sequences of 3000 IQ domain regions.

FIG 8

The sequence is numbered in relation to the first residue (0) in the 11 residue IQ motif, which has been underlined. Each position is represented by a stack of one-letter amino acid symbols. The total height of a stack is an indication of how well conserved that position is; the height of each amino acid symbol in a stack is an indication of its relative frequency. The arrow indicates a semi-conserved Gly residue that appears to be a major determinant of the pattern of Ca2+-dependent stability changes exhibited by a CaM-IQ domain complex.