Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 21;4(12):e8391. doi: 10.1371/journal.pone.0008391

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Ichikawa et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Under normal conditions, a single Keap1 protein is able to target multiple Nrf2 proteins for destruction via ubiquitin-proteasome system, and only a small portion of Nrf2 proteins is translocated into the nuclus to activate Nrf2-driven transcription. Dh404 interacts with Cys-151 of Keap1 to inhibit the Keap1-dependent degradation of Nrf2. Thus, newly synthesized Nrf2 proteins saturate the capacity of Keap1 binding with Nrf2, accumulate in the cytoplasm and subsequently translocate into the nucleus, thereby facilitating Nrf2-driven transcription of antioxidant genes to protect against oxidative stress.