Table 4.
Top 10 characteristic genes of group 2 carcinogens at 28th day.
| Gene name | Unigene ID | Description | Gene ontology (Biological process) | Welch’s t-value | Mean of log2 ratio |
|---|---|---|---|---|---|
| Glutamyl-prolyl-tRNA synthetase | Rn.21240 | – | prolyl-tRNA aminoacylation, protein complex assembly, tRNA aminoacylation for protein translation | 4.28 | 0.74 |
| CCAATenhancer binding protein (CEBP), beta | Rn.6479 | transcription factor that binds to CCAATT motif on DNA and may facilitate IL-6 induced transcriptional activation | transcription from RNA polymerase II promoter, neuron differentiation, fat cell differentiation | 4.16 | 0.23 |
| CD63 antigen | Rn.11068 | human homolog facilitates endocytosis of H,K-ATPase beta-subunit; may play a role in protein trafficking | positive regulation of endocytosis | 3.87 | −0.38 |
| Lymphotoxin B receptor | Rn. 19329 | – | lymph node development, signal transduction, positive regulation of l-kappaB kinase/NF-kappaB cascade | 3.86 | 0.66 |
| Similar to putative protein, with at least 6 transmembrane domains, of ancient origin (58.5 kD) (3N884) (predicted) | Rn. 152690 | – | metabolism | 3.80 | 0.15 |
| Alpha-fetoprotein | Rn.9174 | plasma protein expressed in the fetal liver and yolk sac | progesterone metabolism, sexual reproduction, ovulation (sensu Mammalia) | 3.69 | 0.28 |
| AFG3(ATPase family gene 3)-like 1 (yeast) (predicted) | Rn.41391 | – | – | 3.67 | 0.64 |
| Transcribed locus | Rn. 120914 | – | – | 3.61 | −0.25 |
| Selenocysteine lyase | Rn. 23954 | mouse homolog catalyzes the decomposition of L-selenocysteine to produce L-alanine and selenium; may function to deliver elemental selenium to selenophosphate synthetase for selenoprotein biosynthesis | metabolic process, amino acid metabolism, selenocysteine catabolism | 3.54 | 0.54 |
| Transcribed locus | Rn. 166039 | – | – | 3.51 | 0.50 |