Table 5.
Top 10 characteristic genes of group 3 carcinogens at 28th day.
| Gene name | Unigene ID | Description | Gene ontology (Biological process) | Welch’s t-value | Mean of log2 ratio |
|---|---|---|---|---|---|
| Transcribed locus | Rn. 164817 | – | – | 5.88 | 1.11 |
| probasin | Rn.9862 | displays androgen dependent expression in prostate epithelial cells | – | 5.57 | −1.68 |
| cd36 antigen | Rn. 102418 | fatty acid translocase; involved in long-chain fatty acid (LCFA) transport; important in fatty acid metabolism and insulin function | blood coagulation, fatty acid transport, long-chain fatty acid transport | 4.98 | 1.97 |
| Transcribed locus | Rn. 164639 | – | – | 4.60 | −0.21 |
| Glial cell line derived neurotrophic factor family receptor alpha 1 | Rn. 88489 | binds glial cell line-derived neurotrophic factor (GDNF) and mediates Ret protein-tyrosine kinase receptor phosphorylation and activation | transmembrane receptor protein tyrosine kinase signaling pathway, nervous system development, cell surface receptor linked signal transduction | 4.57 | −0.73 |
| RT1 class II, locus Ba | Rn. 25717 | may play a role in antigen presentation | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response | 4.46 | −0.54 |
| Dehydrogenasereductase (SDR family) member 7 | Rn. 119024 | exhibits oxidoreductase activity; involved in metabolic process (inferred) | metabolic process | 4.46 | −2.46 |
| PYD and CARD domain containing | Rn.7817 | may play a role in apoptosis | induction of apoptosis, regulation of caspase activity, positive regulation of interleukin-1 beta secretion | 4.45 | −0.45 |
| Steroid 5 alpha-reductase 1 | Rn.4620 | catalyzes the conversion of testosterone to dihydrotestosterone; required for male sex differentiation | sex determination, androgen biosynthesis, male sex differentiation | 4.43 | 1.07 |
| Prolactin receptor | Rn.9757 | high affinity receptor for prolactin (PRL); may mediate prolactin functions in brain including reproduction, sexual behavior, feeding behavior, and maternal behavior; may play a role in regulation of GnRH secretion, firing rate of hypothalamic neurons, metabolism of neurotransmitters and neuropeptides, oxytocin release, enzyme activities in neurons, and glial cell proliferation | embryo implantation, regulation of epithelial cell differentiation, regulation of cell adhesion | 4.38 | 2.01 |