Table 2.

Risk of Cardiovascular Event According to Baseline BMD (Lowest Quartile vs. Higher Three Quartiles) in 743 Men, MINOS Study, 1995–2003

BMD	HR (95% CI) comparing lowest quartile vs. three upper quartiles
	Age-adjusted	Fully adjusted
Spine* (<0.910 g/cm2)	1.95 (1.17–3.25)†	1.60 (0.94–2.72)
Femoral neck (<0.756 g/cm2)	1.19 (0.71–1.99)	1.33 (0.77–2.27)
Trochanter (<0.657 g/cm2)	1.65 (1.03–2.64)†	1.56 (0.94–2.60)
Total hip (<0.872 g/cm2)	1.58 (0.98–2.53)	1.59 (0.93–2.74)
Whole body (<1.131 g/cm2)	2.20 (1.40–3.46)‡	1.78 (1.05–3.03)†
Distal forearm (<0.477 g/cm2)	1.79 (1.16–2.87)†	1.51 (0.88–2.55)
Ultradistal radius (<0.386 g/cm2)	2.23 (1.41–3.53)§	1.65 (0.99–2.75)

Adjusted for age, weight, height (all continuous), education (>8 vs. ≤8 yr), occupational physical activity (low to medium vs. high to very high), smoking (current smoker, former smoker >25 packet-years, former smoker ≤25 packet-years, never smoker), ischemic heart disease, hypertension, diabetes (all yes/no), use of thiazides, use of vitamin K–inhibiting anticoagulants, and lowest 25(OH)D quartile.

Values in parentheses represent the cut-off value of the first quartile.

* Adjusted additionally for lumbar osteoarthritis.

^† p < 0.05.

^‡ p < 0.01.

^§ p < 0.001.