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Sample size estimates for AD from a linear mixed-effects model with random slopes. The bars, with 95% confidence intervals, indicate the expected number of subjects needed per arm to detect a 25% reduction in rate of change at the P < 0.05 level with 80% power, assuming a 24-month trial with scans every 6 months. Results for Model T are in blue and results for Model D are in red; numerical values are shown in Table 1.
