Table 1.
Sample size estimates (N) and annualized percent change for AD
| Measure | AD only N | AD-HC N | AD % change* | HC % change* |
|---|---|---|---|---|
| Entorhinal | 45 [39 53] | 65 [52 83] | −3.81 [−4.10 −3.52] | −0.64 [−0.85 −0.43] |
| Inf temporal | 79 [65 97] | 117 [92 153] | −3.64 [−4.00 −3.28] | −0.65 [−0.76 −0.53] |
| Fusiform | 72 [60 88] | 114 [90 149] | −2.90 [−3.17 −2.62] | −0.59 [−0.68 −0.50] |
| Mid temporal | 83 [69 103] | 122 [95 162] | −3.44 [−3.79 −3.09] | −0.60 [−0.73 −0.47] |
| Hippocampus | 67 [56 82] | 118 [91 158] | −3.28 [−3.58 −2.98] | −0.80 [−0.95 −0.65] |
| Inf lat vent | 76 [63 94] | 157 [117 221] | 15.56 [14.04 17.09] | 4.71 [3.95 5.47] |
| Whole brain | 101 [81 128] | 189 [139 271] | −1.50 [−1.67 −1.33] | −0.40 [−0.47 −0.34] |
| Ventricles | 86 [71 108] | 240 [168 371] | 11.06 [9.91 12.21] | 4.43 [3.83 5.03] |
| CDR-SOB | 226 [159 345] | 236 [165 365] | 1.76 [1.43 2.10] | 0.04 [0.00 0.07] |
| ADAS-Cog† | 324 [217 536] | 283 [192 457] | 4.84 [3.76 5.92] | −0.34 [−0.59 −0.09] |
| MMSE† | 482 [299 907] | 494 [303 948] | −2.45 [−3.11 −1.78] | −0.03 [−0.14 0.08] |
Values in brackets are 95% confidence intervals. ADAS-Cog, Alzheimer's Disease Assessment Scale—Cognitive; CDR-SOB, clinical dementia rating, sum of boxes; HC, healthy controls; MMSE, Mini-Mental State Examination.
*Annual percent change in volume for all entries except CDR-SOB, ADAS-Cog, and MMSE.
†Not shown in Fig. 2.