Table 2.

Sample size estimates (N) and annualized percent change for MCI

Measure	MCI only N	MCI-HC N	MCI % change*	HC† % change*
Entorhinal	135 [115 161]	241 [180 340]	−2.54 [−2.75 −2.33]	−0.64 [−0.85 −0.43]
Inf temporal	199 [164 246]	449 [324 664]	−1.93 [−2.13 −1.74]	−0.65 [−0.76 −0.53]
Fusiform	185 [153 227]	485 [345 733]	−1.54 [−1.69 −1.39]	−0.59 [−0.68 −0.50]
Mid temporal	229 [186 288]	501 [353 768]	−1.84 [−2.04 −1.64]	−0.60 [−0.73 −0.47]
Hippocampus	179 [149 220]	510 [350 811]	−1.96 [−2.15 −1.78]	−0.80 [−0.95 −0.65]
Inf lat vent	160 [135 194]	550 [371 897]	10.23 [9.30 11.16]	4.71 [3.95 5.47]
Whole brain	158 [133 190]	541 [367 875]	−0.88 [−0.96 −0.80]	−0.40 [−0.47 −0.34]
Ventricles	189 [157 233]	1,141 [662 2,421]	7.47 [6.73 8.21]	4.43 [3.83 5.03]
CDR-SOB	490 [356 715]	551 [388 842]	0.67 [0.55 0.78]	0.04 [0.00 0.07]
ADAS-Cog‡	1,232 [748 2,403]	804 [500 1,502]	1.44 [1.03 1.84]	−0.34 [−0.59 −0.09]
MMSE‡	1,214 [744 2,322]	1,304 [751 2,800]	−0.84 [−1.08 −0.61]	−0.03 [−0.14 0.08]

*Annual percent change in volume for all entries except CDR-SOB, ADAS-Cog, and MMSE.

^†Normal values reproduced from Table 1.

^‡Not shown in Fig. 3.