Table 1.
Rate of myelin formation and the diameters for different internodes were measured during premyelination and myelination periods by Schwann cells in neuronal cocultures
| Rate of myelin formation
|
|||
|---|---|---|---|
| (Radiance value change/hr) | Diameter, μm | ||
| Dorsal root ganglia axons alone | 0.9 ± 0.2 | 0.8 ± 0.1 | |
| Premyelinating internodes (0–2 days after induction) | Day 0 | Day 2 | |
| Control | 1.1 ± 0.2 | 0.8 ± 0.2 | 1.2 ± 0.3 |
| Myelinating internodes (3–5 days after induction) | Day 3 | Day 5 | |
| Control | 5.1 ± 0.9 | 1.9 ± 0.1 | 3.0 ± 0.4 |
| +Progesterone | 10.5 ± 1.2 | 2.2 ± 0.2 | 2.9 ± 0.6 |
| +RU486 | 2.4 ± 0.9 | 1.6 ± 0.1 | 1.8 ± 0.3 |
| +R5020 | 10.0 ± 1.6 | 2.0 ± 0.1 | 3.1 ± 0.4 |
| +Dexamethasone | 11.2 ± 1.7 | 1.9 ± 0.2 | 3.0 ± 0.4 |
| +Basic fibroblast growth factor | 5.4 ± 1.0 | 1.8 ± 0.3 | 3.2 ± 0.3 |
| +Platelet-derived growth factor | 5.0 ± 1.2 | 2.0 ± 0.4 | 2.9 ± 0.3 |
| Mature myelin internodes (7–10 days after induction) | |||
| Control | 1.0 ± 0.2 | 3.0 ± 0.4 | |
| +Progesterone | 1.1 ± 0.5 | 2.9 ± 0.6 | |
| +Dexamethasone | 1.2 ± 0.3 | 3.0 ± 0.4 | |