Table 3.
STUDY | TREATMENT, SUBJECTS, AND SCALESa | NNT |
---|---|---|
Biederman et al, 2007 (4 weeks)27 | LDX (n=214) vs. placebo (n=72). Children. % CGI respondersa | 2 |
Greenhill et al, 2002 (3 weeks)28 | MR-MPH (n=155) vs. placebo (n=159). Children and adolescents. % CGI respondersa | 3 |
Kratochvil et al, 2005 (5 weeks)29 | Atomoxetine + fluoxetine (n=127) vs. atomoxetine+placebo (n=46). Children and adolescents. % responders: ADHD-RS or CDRS-R scores 1 SD of age and sex norms | ADHD-RS, 12; CDRS-R, 6 |
Kuperman et al, 2001 (7 weeks)30 | SR-bupropion (n=11) vs. MPH (n=8) vs. placebo (n=8). Adults. % CGI respondersa | Bupropion vs. placebo, 3; MPH vs. placebo, 4 |
Pliszka et al, 2000 (3 weeks)31 | MAS (n=20) vs. MPH (n=20) vs. placebo (n=18). Children. % CGI respondersa | MAS vs. placebo, 2; MPH vs. placebo, 3 |
Reimherr et al, 2007 (4 weeks)32 | OROS-MPH (n=47) vs. placebo. Crossover study. Adults. % responders: ≥50% improvement in WRAADDS scores | 3 |
Riggs et al, 2004 (12 weeks)33 | Pemoline (n=34) vs. placebo (n=33). Adolescents. % CGI respondersa | 5 |
Safren et al, 2005 (15 weeks)34 | Cognitive-behavioral therapy + ADHD medications (n=16) vs. ADHD medications (n=15). Adults. % CGI respondersa | 2 |
Spencer et al, 2005 (6 weeks)35 | MPH (n=104) vs. placebo (n=42). Adults. % responders: % CGI respondersa + >30% reduction in AISRS scores | 2 |
Weiss et al, 2006 (20 weeks)35 | DEX (n=23) vs. paroxetine (n=24) vs. placebo (n=26). Adults. % CGI respondersa | DEX vs. paroxetine, 2; vs. placebo, 2 |
Patients with CGI ratings of much or very much improved (score 1 or 2).
- ADHD
attention-deficit/hyperactivity disorder
- ADHD-RS
ADHD Rating Scale IV
- AISRS
Adult ADHD Investigator System Report Scale
- CDRS-R
Children’s Depression Rating Scale–Revised
- CGI
Clinical Global Impressions scale
- DEX
dextroamphetamine
- LDX
lisdexamfetamine
- MAS
mixed amphetamine salts
- MPH
methylphenidate
- MR
modified release
- OROS
osmotic-release oral system
- SD
standard deviation
- SR
sustained release
- WRAADDS
Wender-Reimherr Adult Attention Deficit Disorder Scale
- XR
extended release