Table 18.1.

Changes in the endocannabinoid system in various types of human cancer

Cancer type	In vivo/in vitro	Changes in the endocannabinoid system	References
Colorectal	In vivo	AEA ↑, 2-AG ↑	Ligresti et al. (2003)
Glioblastomas	In vivo	AEA ↑, FAAH ↓, Phopholipase D ↓, VR1 ↑	Contassot et al. (2004b) and Petersen et al. (2005)
Meningioma	In vivo	2-AG ↑	Petersen et al. (2005)
Pituitary adenomas		AEA ↑, 2-AG ↑, Cb1 ↑	Pagotto et al. (2001)
Prostate carcinoma	In vivo	AEA ↑, Cb1 ↑, Cb2 ↑	Schmid et al. (2002) and Sarfaraz et al. (2005)
Endometrial sarcoma	In vivo	AEA ↑	Schmid et al. (2002)
Thigh histiocytoma	In vivo	AEA ↑	Schmid et al. (2002)
Stomach carcinoma	In vivo	AEA ↓	Schmid et al. (2002)
Mantle cell lymphoma	In vivo	Cb1 ↑, Cb2 ↑	Ek et al. (2002) and Islam et al. (2003)
Acute myeloid leukemia	In vitro	Cb2 ↑	Alberich Jorda et al. (2004)
Breast cancer	In vivo	Cb1 ↓, Cb2 ↓	Caffarel et al. (2006)