Fig. 4.

Histopathology from ATPalpha alleles. a–g Brain histology from aged ATPalpha ^CJ alleles and control tissues. b ATPalpha ^CJ12 animals exhibit modest neuropathology akin to that observed in aged wild-type control brains (a). ATPalpha ^CJ13 and ATPalpha ^CJ10 exhibit marked neuropathology as is evident by vacuolar and spongiform-like neuropath throughout the neuropil and optic lobes (c and d, respectively). e ATPalpha ^CJ7 exhibits a fine vacuolar pathology that is more clearly observed at higher magnification as seen in g (compare to panel f from wild type). h–j Muscle histology from aged animals. Wild-type and ATPalpha ^CJ5 mutants do not exhibit significant myopathology in aged specimens (h and j, respectively). I ATPalpha ^CJ12 do exhibit pathology. Bars are all 100 µm. Histopathology was obtained from animals at the median age for their genotype