Fig. 7.

Longevity and stress-sensitive locomotor impairment in ATPalpha alleles. a Progressive locomotor impairment in heterozygous ATPalpha mutants. Recovery from mechanical stress-induced paralysis (seconds) was measured in ATPalpha mutants and aged-matched wild type controls at 25°C. Paralysis was never observed in wild type controls, but all mutant lines showed some degree of progressive impairment by 20–30 days post-eclosion. Asterisks indicate significant differences from age-matched wild type controls using a Student’s t test (* P < 0.001). Time points examined are days 3, 10 and 30 post-eclosion. b Lifespans were performed on heterozygous ATPalpha mutant and control animals. Median lifespan was used to compare longevity between the genotypes. Asterisks indicate significant differences from wild type controls using a Student’s t test (* P < 0.05, ** P < 0.01, and *** P < 0.001). Error is SEM