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. Author manuscript; available in PMC: 2010 Sep 18.
Published in final edited form as: J Org Chem. 2009 Sep 18;74(18):7122–7131. doi: 10.1021/jo901494r

Table 1.

Antiproliferative Activity of 5, 6, 7, 23 and 27.

compound % cell viabilitya compound % cell viabilitya
HeLa MCF-7/AZ HeLa MCF-7/AZ
6 78 ± 3 83 ± 5 23 89 ± 4 92 ± 3
5 70 ± 9 82 ± 11 27 60 ± 3 64 ± 6
7 59 ± 8 48 ± 3 narciclasine 6 ± 1 8 ± 2
a

% cell viability after 48 h of treatment with indicated compounds at 300 μM relative to DMSO control ± SD from two independent experiments, each performed in 8 replicates, determined by MTT assay.