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Phylogenetic tree based on SH2 domain sequence and domain organization in nonreceptor tyrosine kinases. The different types of domain architectures shown in the lower panel are highlighted by different colors and in the phylogenetic tree the name of kinases with a certain domain organization are colored accordingly. The SH2–kinase unit is indicated by a dashed line. In Jak kinases this unit involves probably both kinase domains, which seem to form a compact structural unit [34].
