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. 2009 Dec 24;5(12):e1000705. doi: 10.1371/journal.ppat.1000705

Figure 8. A model for the role ESCRT proteins in tombusvirus replication.

Figure 8

Recruitment of Vps23p and/or Bro1p to the peroxisomal membrane by a small fraction of p33 is suggested to lead to the recruitment of additional ESCRT factors. Then, ESCRT-III and Vps4p factors facilitate the precise assembly of the replicase that is needed to prevent the recognition of the virus by the host surveillance system and prevent the destruction of the viral RNAs in the spherule by the host gene silencing machinery.