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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: J Nucl Med. 2009 Apr 16;50(5):749–756. doi: 10.2967/jnumed.108.058305

FIGURE 2.

FIGURE 2

T2-weighted MR (upper) and PET images obtained at 20–40 min (lower). MR images are displayed from rostral (left) to caudal (right) direction. 11C-(R)-rolipram PET scans were obtained at baseline (lower left), with 3.0 μg/kg dose of nonradiolabeled (R)-rolipram (lower middle), or saturating (1.0 mg/kg, lower right) dose of nonradiolabeled (R)-rolipram. PET images are in same location as middle of 3 MR images. Intensity of PET images is area under curve of radioactivity without including nonlabeled (R)-rolipram between 20 and 40 min. Value of 100% standardized uptake value (%SUV) is equal to concentration of radioligand that would be achieved if it were uniformly distributed in body.