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. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: J Nucl Med. 2009 Apr 16;50(5):749–756. doi: 10.2967/jnumed.108.058305

Concentration of radioactivity in hippocampus of conscious rat and 2-compartment fitting. Total concentration of radioactivity in hippocampus (×) and serial concentrations of ¹¹C-(R)-rolipram in arterial plasma (not shown) were fit with 2-tissue-compartment model (). The 2 tissue compartments were composed of specifically bound () and nondisplaceable uptake (●●●). Concentrations of bound (R)-rolipram were measured when specific binding reached to peak (superior cross hair). At same time point, free concentrations were calculated, in part, on the basis of uptake in nondisplaceable compartment (inferior cross hair, $C_{ND}^{E}$ ). In this study, peak specific uptake occurred at approximately 10 min, at which time specific binding was approximately 262% SUV, and nondisplaceable uptake was approximately 27% SUV.

Inline graphic — Concentration of radioactivity in hippocampus of conscious rat and 2-compartment fitting. Total concentration of radioactivity in hippocampus (×) and serial concentrations of ¹¹C-(R)-rolipram in arterial plasma (not shown) were fit with 2-tissue-compartment model (). The 2 tissue compartments were composed of specifically bound () and nondisplaceable uptake (●●●). Concentrations of bound (R)-rolipram were measured when specific binding reached to peak (superior cross hair). At same time point, free concentrations were calculated, in part, on the basis of uptake in nondisplaceable compartment (inferior cross hair, $C_{ND}^{E}$ ). In this study, peak specific uptake occurred at approximately 10 min, at which time specific binding was approximately 262% SUV, and nondisplaceable uptake was approximately 27% SUV.