. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: J Nucl Med. 2009 Apr 16;50(5):749–756. doi: 10.2967/jnumed.108.058305

TABLE 1.

In Vivo B_max and K_D of ¹¹C-(R)-Rolipram Measured in Brain Regions of Conscious and Anesthetized Rats

	B_max (nM)		K_D (nM)
Region	Conscious Anesthetized Conscious Anesthetized
Caudate putamen	93.3	68.6	1.46	0.81
Thalamus	70.0	57.4	1.17	0.91
Hypothalamus	61.2	33.9	1.53	0.59
Hippocampus	79.7	54.3	1.57	0.73
Frontal cortex	68.3	64.8	1.10	0.97
Parietal cortex	72.6	64.6	1.36	1.09
Temporal cortex	64.7	52.8	1.25	0.84

Each set of B_max and K_D values was calculated by nonlinear least-squares fitting of 1-binding-site model applied to saturation data. Significant differences were found between conscious and anesthetized rats in both mean B_max (P = 0.019) and K_D (P = 0.004) values by Student t test in all regions.