. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: J Nucl Med. 2009 Apr 16;50(5):749–756. doi: 10.2967/jnumed.108.058305

TABLE 2.

B_max and K_D of (R)-Rolipram Measured In Vivo and In Vitro in Regions of Rat Brain

	B_max (nM)			K_D (nM)
	In vivo			In vivo
Region	Conscious	Anesthetized	In vitro	Conscious	Anesthetized	In vitro
Frontal cortex	68.3	64.8	84 ± 6	1.10	0.97	5.5 ± 0.3
Hippocampus	79.7	54.3	66 ± 6	1.57	0.73	5.4 ± 0.3
Diencephalon	66.7	48.6	81 ± 8	1.31	0.79	6.1 ± 0.3

Values from in vitro studies are mean ± SD. In vitro K_D published in Fujita et al. (13) measured with racemic ³H-rolipram was divided by 2 to calculate K_D of (R)-rolipram.