Table 3.
SNPs associated with plasma IL-6 concentration in CHS European-Americans
| SNP rs# | Gene | Chr | Position (bp) |
Location | Minor allele frequency |
Correlated SNP |
r2 with reference SNP |
Regression coefficient ± standard error* |
p-value |
|---|---|---|---|---|---|---|---|---|---|
| rs4537545 | IL6R | 1 | 152685503 | intron | 0.41 | Tag SNP | -- | 0.114 ± 0.013 | 3 × 10−18 |
| rs7518199 | IL6R | 1 | 152674043 | intron | 0.41 | Typed SNP | 0.88 | 0.101 ± 0.013 | 3 × 10−18 |
| rs8192284 | IL6R | 1 | 152693594 | Ala358Asp | 0.35 | HapMap SNP | 0.96 | -- | -- |
| rs4553185 | IL6R | 1 | 152677579 | Intron | 0.43 | Tag SNP | -- | −0.082 ± 0.013 | 3 × 10−10 |
| rs4845618 | IL6R | 1 | 152666639 | Intron | 0.43 | Typed SNP | 0.96 | −0.078 ± 0.013 | 3 × 10−10 |
| rs4072391 | IL6R | 1 | 152705504 | 3′ UTR | 0.19 | Tag SNP | −0.076 ± 0.017 | 5 × 10−6 | |
| rs2229238 | IL6R | 1 | 152704520 | 3′ UTR | 0.19 | Typed SNP | 0.98 | −0.079 ± 0.017 | 5 × 10−6 |
| rs1805415 | PARP1 | 1 | 224637463 | Lys352Lys | 0.15 | Tag SNP | -- | 0.095 ± 0.025 | 1 × 10−4 |
| rs752307 | PARP1 | 1 | 224618152 | intron | 0.16 | Typed SNP | 0.997 | 0.067± 0.018 | 2 × 10−4 |
| rs1136410 | PARP1 | 1 | 224621925 | Val762Ala | 0.17 | HapMap SNP | 1.00 | -- | -- |
*
Regression coefficient equals the estimated change in log(IL-6) level per each additional copy of the minor allele.
Adjusted for age, sex, clinic, BMI, and smoking.