Figure 1.

Anticoagulant activity of mouse, human and bovine APC in human, bovine, rat and mouse plasma. Increasing concentrations of mouse (●), human (▵), and bovine APC (□) were added to bovine (A), human (B), rat (C) and mouse (D) plasma specimens and APTT clotting assays were performed. Each experiment was performed in triplicate and mean values with standard deviation are presented. The indicated concentrations of APC refer to its concentration in the APC reagent solutions that were used for the protocol as detailed in the Design and Methods section.