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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Histol Histopathol. 2009 Aug;24(8):1081–1086. doi: 10.14670/hh-24.1081

Figure 1. Redistribution of TDP-43 is caspase-dependent.

Figure 1

Wild-type (WT) TDP-43 redistributes from the nucleus to the cytoplasm following treatment of H4 cells with the apoptotic insult, staurosporine (Stspn). However, under similar conditions when a caspase-resistant mutant of TDP-43 was expressed, sub-cellular redistribution to the cytoplasm did not occur (top right and bottom of Panel). These experiments were carried out using a mutant form of TDP-43 in which the consensus motif for caspase cleavage at two different sites was mutated. Reproduced with permission from Zhang et al. (Zhang et al., 2007).