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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Histol Histopathol. 2009 Aug;24(8):1081–1086. doi: 10.14670/hh-24.1081

Figure 2. Caspase-cleaved TDP-43 within Hirano bodies in Alzheimer's and Pick's disease.

Figure 2

Both panels depict immunofluorescence labeling utilizing a caspase-cleavage site-directed antibody to TDP-43 (Rohn, 2008). Panel A reflects representative labeling in an Alzheimer's case and along with staining of a Hirano body (arrow), labeling within plaques is also observed. A similar staining profile was observed in Pick's disease (B), and in additional to labeling of Hirano bodies, staining of Pick bodies was also evident. All scale bars represent 10 μm.