Figure 2.

(A) The attachment process of HIV onto its host T cell depends on interaction between viral gp120 with T cell CD4 receptor (TCR) and coreceptor CCR5. (B) The viral protein gp41 is now able to form a pore into the host cell membrane, which allows the entry of viral DNA and enzymes into the T cell. (C) Maraviroc distorts the completion of the binding complex, because it occupies the coreceptor CCR5. (D) Without a complete binding complex the desired conformational change cannot occur and thus the gp41 protein cannot attach, prohibiting injection of viral RNA into the host cell