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Inhibition of carbonic anhydrase (CA) II, IV and XII assayed by spectrophotometric methods based on the CO2 hydrase activity of topiramate by Supuran's group [32]
| CA | Ki* (nm) |
|---|---|
| II | 10 |
| IV | 4900 |
| XII | 3.8 |
Ki refers to the dissociation constant for binding of topiramate to CA with low Ki indicating high affinity.
