Table 1.
Demographic characteristics of study subjects
| CYP2C19 genotype* | ||||
|---|---|---|---|---|
| Parameter | All subjects | Extensive metabolizer (*1*1) | Heterozygous poor metabolizer (*1*2) | Homozygous poor metabolizer (*2*2) |
| n | 68 | 38 | 22 | 6 |
| Gender, n (%) | ||||
| Male | 44 (64.7) | 25 (65.8) | 13 (59.0) | 4 (66.6) |
| Female | 24 (35.3) | 13 (34.2) | 9 (41.0) | 2 (33.4) |
| Age, years | ||||
| Mean (range) | 32.0 (19.0–55.0) | 31.7 (19.0–54.0) | 32.7 (19.0–54.0) | 25.5 (19.0–37.0) |
| Race, n (%) | ||||
| White | 34 (50.0) | 21 (55.3) | 8 (36.4) | 4 (66.6) |
| Black | 12 (17.6) | 7 (18.4) | 4 (18.2) | 1 (16.7) |
| Asian | 18 (26.5) | 7 (18.4) | 9 (40.9) | 1 (16.7) |
| Other | 4 (5.9) | 3 (7.9) | 1 (4.5) | 0 (0.0) |
| Weight, kg | ||||
| Mean (range) | 72.9 (52.0–96.0) | 73.5 (53.0–92.0) | 72.2 (52.0–96.0) | 70.3 (59.0–82.0) |
| BMI, kg m–2 | ||||
| Mean (range) | 24.6 (18.7–29.8) | 25.0 (18.7–29.8) | 24.5 (20.7–29.0) | 23.2 (21.7–26.6) |
*
Two subjects were classified as having the *1*3 and *1*4 genotype, and were excluded.