Table 2.
Univariate stepwise inclusion of pharmacogenetic covariates on efavirenz CL/F or Frel in the pharmacokinetic model
| Variable | OFV (CL/F) | P-value | OFV (Frel) | P-value |
|---|---|---|---|---|
| Pharmacokinetic model | 471.5 | – | 471.5 | – |
| CYP3A5*3 | 469.4 | NS | 462.1 | <0.01 |
| CYP3A5*4 | 469.2 | NS | 467.0 | <0.05 |
| CYP3A5*6 | 469.4 | NS | 469.0 | NS |
| CYP3A5*7 | 470.3 | NS | 467.0 | <0.05 |
| CYP3A5*9 | 469.4 | NS | 463.1 | <0.01 |
| CYP2B6*2 | 470.0 | NS | 460.8 | NS |
| CYP2B6*11 | 467.0 | <0.05 | 471.4 | NS |
| CYP2B6*21 | 470.0 | NS | 468.6 | NS |
| CYP2B6*15 | 471.2 | NS | 470.0 | NS |
| CYP2B6*18 | 471.4 | NS | 468.9 | NS |
| CYP2B6(516G→T) | 466.3 | <0.05 | 459.7 | <0.01 |
| CYP2B6(785A→G) | 466.5 | <0.05 | 458.1 | <0.01 |
| ABCB1 (rs1202168) | 470.5 | NS | 468.8 | NS |
| ABCB1 (rs478699) | 469.6 | NS | 464.4 | <0.05 |
| ABCB1(rs36008564) | 471.5 | NS | 467.3 | <0.05 |
| ABCB1(rs92822565) | 471.3 | NS | 470.1 | NS |
| ABCB1(rs2035282) | 463 | <0.05 | 469.9 | NS |
| ABCB1(rs3842) | 469.2 | NS | 463.3 | <0.01 |
| ABCB1(rs20328588) | 469.36 | NS | 458.0 | <0.01 |
| ABCB1(rs2235036) | 468.9 | NS | 459.2 | <0.01 |
| ABCB1(3435 C→T) | 466.5 | <0.05 | 469.3 | NS |
| ABCB1(1236 C→T) | 471.3 | NS | 469.7 | NS |
OFV, objective function value. P-value obtained through the use of the log-likelihood test ratio where a difference of 3.84 corresponds to a P-value of 0.05.