Table 2.
Drugs prescribed (used) within the 30 days prior to death of the case
| Casesn | Controlsn | OR | 95% CI | Adjusted OR | 95% CI | |||
|---|---|---|---|---|---|---|---|---|
| Arizona Group 1 | ||||||||
| Amiodarone | 17 | 17 | 3.0 | 1.53 | 5.88 | 1.99 | 0.93 | 4.28 |
| Chlorpromazine | 4 | 8 | 1.5 | 0.45 | 4.98 | 1.28 | 0.34 | 4.86 |
| Clarithromycin | 2 | 6 | 1.0 | 0.20 | 4.95 | 0.94 | 0.18 | 5.07 |
| Disopyramide | 0 | 1 | – | – | – | – | – | – |
| Domperidone | 6 | 12 | 1.5 | 0.56 | 4.00 | 1.60 | 0.59 | 4.36 |
| Erythromycin | 8 | 12 | 2.0 | 0.82 | 4.89 | 2.07 | 0.82 | 5.24 |
| Haloperidol | 6 | 3 | 6.0 | 1.50 | 23.99 | 3.63 | 0.84 | 14.64 |
| Methadone | 1 | 1 | 3.0 | 0.19 | 47.96 | 3.78 | 0.23 | 61.43 |
| Sotalol | 5 | 14 | 1.07 | 0.39 | 2.97 | 1.03 | 0.36 | 2.99 |
| Thioridazine | 2 | 0 | – | – | – | – | – | – |
| Any type I drug | 50 [51] | 74 [74] | 2.08 | 1.45 | 3.00 | 1.76 | 1.19 | 2.62 |
| Arizona Group 2 | ||||||||
| Alfuzosin | 5 | 31 | 0.48 | 0.18 | 1.24 | 0.60 | 0.22 | 1.55 |
| Amantadine | 2 | 1 | 6.0 | 0.54 | 66.17 | 11.18 | 0.94 | 132.68 |
| Chloral hydrate | 2 | 1 | 6.0 | 0.54 | 66.17 | 5.48 | 0.48 | 62.34 |
| Clozapine | 1 | 0 | – | – | – | – | – | – |
| Flecainide | 1 | 4 | 0.75 | 0.08 | 6.71 | 0.70 | 0.07 | 6.82 |
| Indapamide | 15 | 67 | 0.65 | 0.37 | 1.16 | 0.77 | 0.42 | 1.42 |
| Levofloxacin | 0 | 2 | – | – | – | – | – | – |
| Lithium | 6 | 10 | 1.8 | 0.65 | 4.95 | 1.75 | 0.62 | 4.95 |
| Nicardipine | 1 | 2 | 1.5 | 0.14 | 16.5 | 2.74 | 0.24 | 31.34 |
| Quetiapine | 3 | 4 | 2.25 | 0.50 | 10.05 | 3.49 | 0.71 | 17.15 |
| Risperidone | 15 | 10 | 4.5 | 2.02 | 10.02 | 4.22 | 1.82 | 9.79 |
| Tamoxifen | 1 | 11 | 0.27 | 0.04 | 2.11 | 0.28 | 0.04 | 2.20 |
| Vardenafil | 0 | 6 | – | – | – | – | – | – |
| Venlafaxine | 10 | 14 | 2.14 | 0.95 | 4.82 | 2.24 | 0.93 | 5.38 |
| All Group 2 | 50 [66] | 138 [159] | 1.09 | 0.78 | 1.53 | 1.30 | 0.93 | 1.80 |
| Arizona Group 3 (not in 1, 2 or 4) | ||||||||
| Ephedrine | 1 | 1 | 3.0 | 0.19 | 47.96 | 1.05 | 0.04 | 24.97 |
| Pseudoephedrine | 1 | 7 | 0.42 | 0.05 | 3.48 | 0.36 | 0.04 | 3.19 |
| Salmeterol | 43 | 110 | 1.18 | 0.82 | 1.70 | 1.13 | 0.77 | 1.66 |
| Sibutramine | 0 | 1 | – | – | – | – | – | – |
| Terbutaline | 9 | 23 | 1.18 | 0.54 | 2.56 | 1.30 | 0.57 | 2.94 |
| Tolterodine | 5 | 16 | 0.94 | 0.34 | 2.56 | 1.03 | 0.35 | 3.03 |
| Any group 3 | 59 [59] | 154 [158] | 0.94 | 0.34 | 2.56 | 1.12 | 0.81 | 1.57 |
| Arizona Group 4 | ||||||||
| Amitriptyline | 16 | 41 | 1.17 | 0.66 | 2.09 | 1.17 | 0.64 | 2.12 |
| Ciprofloxacin | 4 | 12 | 1.0 | 0.32 | 3.10 | 0.78 | 0.25 | 2.50 |
| Citalopram | 19 | 25 | 2.28 | 1.25 | 4.14 | 1.83 | 0.97 | 3.56 |
| Clomipramine | 2 | 4 | 1.5 | 0.27 | 8.19 | 1.63 | 0.28 | 9.35 |
| Fluconazole | 0 | 1 | – | – | – | – | – | – |
| Fluoxetine | 18 | 24 | 2.29 | 1.23 | 4.24 | 2.11 | 1.08 | 4.20 |
| Imipramine | 1 | 5 | 0.6 | 0.07 | 5.14 | 0.63 | 0.07 | 5.36 |
| Nortriptyline | 0 | 1 | – | – | – | – | – | – |
| Paroxetine | 10 | 19 | 1.60 | 0.73 | 3.48 | 0.93 | 0.44 | 2.23 |
| Sertraline | 9 | 9 | 3.0 | 1.19 | 7.55 | 2.90 | 1.07 | 7.99 |
| Solifenacin | 1 | 3 | 1.0 | 0.10 | 9.61 | 1.21 | 0.11 | 12.18 |
| Trimethoprim | 11 | 17 | 1.94 | 0.91 | 4.14 | 1.73 | 0.75 | 3.87 |
| Trimipramine | 1 | 0 | – | – | – | – | – | – |
| Any Group 4 | 88 [92] | 157 [161] | 1.74 | 1.33 | 2.28 | 1.49 | 1.13 | 1.99 |
Adjusted for heart failure, MI, atrial fibrillation, revascularization, hypokalaemia, bradycardia, syncope, epilepsy, renal dysfunction, history of alcohol abuse.