Table 3.
Odds ratio (OR) (crude and adjusted) for categories of psychiatric drugs 0–30 days
| Crude OR | 95% CI | Adjusted OR* | 95% CI | |||
|---|---|---|---|---|---|---|
| All antipsychotics | 4.27 | 2.78 | 6.59 | 4.29 | 2.68 | 6.88 |
| High dose | 5.59 | 2.84 | 10.98 | 5.64 | 2.66 | 11.98 |
| Low dose | 4.02 | 2.11 | 7.68 | 4.65 | 2.36 | 9.19 |
| Injected/depot | 2.17 | 0.61 | 7.77 | 1.31 | 0.34 | 6.58 |
| Typical antipsychotics† | 3.94 | 2.05 | 7.55 | 3.35 | 1.64 | 6.83 |
| Atypical antipsychotics‡ | 4.36 | 2.54 | 7.51 | 4.97 | 2.78 | 8.90 |
| Tricyclic antidepressants§ | 1.44 | 0.96 | 2.13 | 1.41 | 0.93 | 2.13 |
| High dose | 2.10 | 0.74 | 3.45 | 2.11 | 1.10 | 4.22 |
| Moderate dose | 0.90 | 0.45 | 1.79 | 0.85 | 0.42 | 1.73 |
| Low dose | 1.61 | 1.07 | 4.08 | 1.60 | 0.72 | 3.56 |
| SSRIs¶ | 2.21 | 1.61 | 3.05 | 1.89 | 1.34 | 2.69 |
| High dose | 3.29 | 1.62 | 6.65 | 2.78 | 1.24 | 6.24 |
| Moderate dose | 1.95 | 1.27 | 2.99 | 1.55 | 0.96 | 2.49 |
| Low dose | 1.75 | 0.69 | 4.44 | 1.83 | 0.70 | 4.78 |
Includes for cases and controls:
chlorpromazine 4 and 8, flupentixol (4 mg plus) 3 and 3, fluphenazine 1 and 2, haloperidol 6 and 3, perphenazine 1 and 0, sulpiride 1 and 0, thioridazine 2 and 0, trifluoperazine 2 and 0, zuclopenthixol 1 and 2;
clozapine 1 and 0, olanzapine 14 and 8, quetiapine 3 and 4, risperidone 15 and 10;
amitriptylline 16 and 41, clomipramine 2 and 4, dosulepin 16 and 26, impramine 1 and 5, lofepramine 1 and 2, nortriptyline 0 and 1, trimipramine 1 and 0, mianserin 1 and 2;
citalopram 19 and 25, escitalopram 4 and 8, fluoxetine 18 and 24, paroxetine, 10 and 19, sertraline 9 and 9, venlafaxine 10 and 14.
Adjusted for heart failure, MI, atrial fibrillation, revascularization, hypokalaemia, bradycardia, syncope, epilepsy, renal dysfunction, history of alcohol abuse.