Table 4.
Adjusted odds ratio (OR) for antipsychotic agents and selective serotonin reuptake inhibitors (SSRIs), in patients with and without prior diagnosed cardiovascular disease, and prescribed for use within 0–30 days of death of the case
| With cardiovascular disease | Without cardiovascular disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Adjusted OR* | 95% CI | Cases | Controls | Adjusted OR† | 95% CI | |||
| All antipsychotics | 27 | 14 | 6.15 | 3.02 | 12.57 | 24 | 25 | 3.26 | 1.67 | 6.36 |
| Haloperidol | 4 | 1 | 7.83 | 0.84 | 72.80 | 2 | 2 | 2.63 | 0.14 | 48.30 |
| Quetiapine | 3 | 3 | 4.24 | 0.80 | 22.41 | 0 | 1 | – | – | – |
| Risperidone | 11 | 1 | 28.70 | 3.61 | 228.06 | 4 | 9 | 1.48 | 0.44 | 4.98 |
| Olanzapine | 5 | 4 | 4.25 | 0.95 | 19.01 | 9 | 4 | 7.40 | 1.94 | 28.23 |
| All SSRI | 45 | 64 | 2.04 | 1.33 | 3.13 | 24 | 34 | 1.63 | 0.86 | 3.10 |
| Citalopram | 12 | 17 | 1.81 | 0.81 | 4.03 | 7 | 8 | 1.70 | 0.50 | 5.99 |
| Paroxetine | 9 | 12 | 1.42 | 0.53 | 3.83 | 1 | 7 | 0.20 | 0.02 | 2.01 |
| Sertraline | 4 | 7 | 2.06 | 0.57 | 7.47 | 5 | 2 | 3.91 | 0.62 | 24.62 |
| Venlafaxine | 9 | 8 | 3.73 | 1.33 | 10.45 | 1 | 6 | 0.67 | 0.07 | 6.19 |
| Fluoxetine | 10 | 15 | 2.26 | 0.96 | 5.34 | 8 | 9 | 2.44 | 0.77 | 7.74 |
| All tricyclics | 24 | 52 | 1.34 | 0.79 | 2.28 | 14 | 29 | 1.61 | 0.83 | 3.13 |
| Amitriptyline | 9 | 25 | 1.07 | 0.48 | 2.40 | 7 | 16 | 1.34 | 0.54 | 3.43 |
| Clomipramine | 1 | 1 | 1.85 | 0.11 | 30.20 | 1 | 3 | 1.64 | 0.16 | 17.24 |
| Dosulepin | 12 | 18 | 2.11 | 0.92 | 4.84 | 4 | 8 | 1.65 | 0.49 | 5.54 |
*
Adjusted for heart failure, MI, revascularization, hypertension, hypokalaemia, hyperkalaemia, epilepsy, syncopy, renal dysfunction, history of alcohol abuse.
†
Adjusted for epilepsy, dizziness, history of drug or alcohol abuse, hypokalaemia and renal dysfunction.