Figure 1.

Alignment of the amino acid residues of the processed human lysyl hydroxylase 3 (Lh3), 1 (Lh1), and 2 (Lh2) polypeptides, and the C. elegans lysyl hydroxylase (C.e.Lh) polypeptide. Gaps (small dots) are introduced for the maximal alignment. Positions of cysteine residues (large dots) and potential N-glycosylation sites (solid lines) in any of the polypeptides are indicated above the sequence. Residues required for the binding of the Fe²⁺ atom and the C-5 carboxyl group of 2-oxoglutarate are indicated by asterisks. White letters on a black background show identity and black letters on a grey background show similarity. Similar amino acids: G, A, S; A, V; V, I, L, M; I, L, M, F, Y, W; L, K, H; D, E, Q, N; S, T, E, N.