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. Author manuscript; available in PMC: 2011 Jan 13.
Published in final edited form as: Brain Res. 2009 Oct 27;1308:35–46. doi: 10.1016/j.brainres.2009.10.050

Table 3.

In vivo microdialysis show effects of NT79 (5 mg/kg) and 2% acetic acid on the levels of 5-HT, DA, and their metabolites in PAG dialysate.

(pg/20μl dialysate) S/S S/AA S/NT79 NT79/AA
5-HT 5±1* 12±2 10±4 3±0.8*
5-HIAA 1600±100 1400±184 800±200 1300±10
DA 1.0±0.2 1.8±0.9 1.0±0.3 1.4±0.2
HVA 60±20 100±50 30±20 400±200
DOPAC 120±40 180±90 40±30 50±10

Rats were treated and samples collected as described in the legend to Figure 9. The monoamine levels were quantitated from measurements of the area under the curve (AUC) and the use of standard curves, which were generated by linear regression analyses (GraphPad Prism, GraphPad Software, Inc., La Jolla, CA, USA). The data represent the meant ± SEM of fractions collected after the second injection.

*

Significantly different from S/AA (P<0.05).

S=saline NT=NT79 AA=acetic acid