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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: J Immunol. 2009 Nov 15;183(10):6377–6386. doi: 10.4049/jimmunol.0901268

Fig. 8.

Fig. 8

Induced Tregs suppress the extramedullary myelopoiesis in the spleen of DO11.10 rag2(-/-) mice. (A) Induced FoxP3+ T cells (iTreg) were prepared by activating DO11.10 rag2(-/-) CD4+ T cells with TGFβ1 for 6 days in vitro. Conventional CD4+ T cells (Conv) were prepared without using TGFβ1. (B) Frequencies of FoxP3+ T cells among splenic CD4+ T cells in the DO11.10 rag2(-/-) mice transferred with iTreg or conventional CD4+ T cells. Frequencies of lineage (CD3/CD19/CD11b)-negative c-Kit+ progenitor cells in the spleen (C), CFU-GM (D), CD11b+GR-1dim cells (E), and CD11b+GR-1bright cells (F) in the spleen of DO11.10 rag2(-/-) mice transferred with iTreg or conventional CD4+ T cells. Averages and SEM of the data obtained from 4-5 mice are shown. *,**Significant differences from the SEB group (*, P < 0.05) or the SEB/conventional T cell group (**, P < 0.05).