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. 2009 Apr 30;15(10):2875–2887. doi: 10.1089/ten.tea.2008.0494

FIG. 4.

FIG. 4.

FIG. 4.

UEA-1-stained sections of endothelialized modules of untreated rats show some vessel formation at day 3 (a), loss of a majority of vessels by day 7 (b), and few UEA-1 cells at day 14 (c). Sections from clodronate-treated animals show UEA-1 cells on the surface of modules at day 3 (d), a number of HUVEC-derived vessels at day 7 (e), and few UEA-1-positive cells at day 14 (f). Collagen-only implants confirm that UEA-1 lectin was HUVEC specific (g, h). Arrows show examples of UEA-1-positive cells, some in the form of vessels. Scale bar = 100 μm. (i) Mean of Chalkley grid counts show that compared to untreated group at day 3, UEA-1 counts were significantly lower (p < 0.05) at days 7 and 14 for untreated animals and at day 14 in the clodronate liposome–treated group (relative to day 3, as marked with an asterisk). The y-axis is the Chalkley grid count, and data are represented as mean of each group (n = 4 for day 3, and n = 5 for days 7 and 14; ±SE). HUVEC, human umbilical vein endothelial cell. Color images available online at www.liebertonline.com/ten.