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. 2009 Apr 30;15(10):2875–2887. doi: 10.1089/ten.tea.2008.0494

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Copyright 2009, Mary Ann Liebert, Inc.

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FIG. 5. — High-magnification (400 ×) UEA-1 sections show HUVEC-derived vessels in both untreated rats and clodronate liposome–treated rats at days 3 and 7. In untreated rats, numerous vessels were located at day 3 (a), while few vessels were found by day 7 (b). In clodronate liposome–treated rats, few vessels were detected at day 3 (c), while numerous vessels of varying sizes were detected at day 7 (d) with erythrocytes present in their lumen. Arrow indicates vessels with lumens. Scale bar = 25 μm. (e) Microvessel density (MVD) counts were significantly lower in the untreated group at day 7 relative to day 3 (p < 0.05). For clodronate liposome–treated animals, an opposite, although not statistically significant, trend was observed as MVD counts increased from day 3 to 7. The mean MVD count for clodronate liposome animals at day 7 was higher (but not significant, p = 0.17) than the corresponding untreated group. The y-axis is the MVD count, and data are represented as means of MVD count (n = 4 for day 3, and n = 5 for day 7; ±SE). Color images available online at www.liebertonline.com/ten.

FIG. 5. — High-magnification (400 ×) UEA-1 sections show HUVEC-derived vessels in both untreated rats and clodronate liposome–treated rats at days 3 and 7. In untreated rats, numerous vessels were located at day 3 (a), while few vessels were found by day 7 (b). In clodronate liposome–treated rats, few vessels were detected at day 3 (c), while numerous vessels of varying sizes were detected at day 7 (d) with erythrocytes present in their lumen. Arrow indicates vessels with lumens. Scale bar = 25 μm. (e) Microvessel density (MVD) counts were significantly lower in the untreated group at day 7 relative to day 3 (p < 0.05). For clodronate liposome–treated animals, an opposite, although not statistically significant, trend was observed as MVD counts increased from day 3 to 7. The mean MVD count for clodronate liposome animals at day 7 was higher (but not significant, p = 0.17) than the corresponding untreated group. The y-axis is the MVD count, and data are represented as means of MVD count (n = 4 for day 3, and n = 5 for day 7; ±SE). Color images available online at www.liebertonline.com/ten.