Table 2.

Macrophage Accumulation Around Endothelialized Modules in Clodronate Liposome–Treated and Control Rats at Days 3, 7, and 14

	Clodronate liposome treated		Untreated
Day	ED1	ED2	ED1	ED2
3	65.9 ± 7.9a	30.4 ± 5.9a	107.4 ± 7.2	82.0 ± 11.0
7	81.5 ± 5.0	78.0 ± 10.8	102.3 ± 11.2	99.0 ± 18.1
14	68.0 ± 8.1	47.9 ± 10.1	85.8 ± 6.0	72.9 ± 9.3

The number of macrophages (ED1 or ED2 positive) around endothelialized modules in four animals per treatment group was counted in five sections at 400 ×, and average of the sections for each group is reported with the standard error. Macrophages were seen around modules at day 3, they peaked at day 7, and reduced by day 14 in both untreated and clodronate liposome–treated animals. When compared to untreated animals, there were fewer ED1- and ED2-positive macrophages with clodronate treatment at day 3 (^ap < 0.01). At later time points, although there were generally fewer macrophages with clodronate treatment, these differences were not statistically significant (day 7, p = 0.07; day 14, p = 0.12).