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Time course of extracellular regulated kinase (ERK)1/2 activation after IL1-β or TNF-α treatment. Representative Western blots obtained from cultures derived from six different bovine carpometacarpal joints are shown. Phosphorylated ERK1/2 was detected rapidly after treatment with IL1-β or TNF-α, and levels remained elevated for up to 15 min. Total levels of ERK protein were unchanged with cytokine treatment. At 25 μM, U0126 completely inhibited ERK1/2 phosphorylation.
