FIG. 10.

As described in Figure 9 but with histological stained sections of constructs composed of midshafts of HA-P(LA-CL). Enlargement of representative cartilage end plates from phalanx constructs whose midshafts are wrapped with periosteum and harvested after 20 weeks of implantation (lower right panel) shows chondrocytes of distinct phenotypes in columnar arrangement resembling normal growth plate tissue (arrows). Cartilage chondrocytes from constructs without periosteal wrapping are viable, as judged by Safranin-O staining, but they are not organized as in a true growth plate (upper right panel). Magnification = 1× (left panels A–D) and 100 × (right panels).