FIG. 2.

A schematic experimental design for tissue engineering model human middle phalanges. Small strips of periosteum, including its cambium layer of pluripotent cells, and cartilage were obtained from calf radii and shoulders, respectively. Intact periosteum was wrapped about each of the three different scaffold composites to fabricate construct midshafts, and chondrocytes isolated from cartilage were seeded onto polyglycolic acid (PGA) used as construct end plates. Some midshaft scaffolds were left uncovered. Middle phalanx models were implanted into nude mice for as long as 20 weeks.