Dose–response of SFB pellets cultivated in the presence of 0, 1, 10, 100, and 500 ng/mL IGF-1 supplemented (a–c) without any TGF-β1 and (d–f) with 10 ng/mL TGF-β1. (a, d) DNA, (b, e) GAG, and (c, f) GAG/DNA contents of pellets cultivated for 14 days are listed as geometric mean ± SE, n = 3. Color images available online at www.liebertonline.com/ten.