Skip to main content
. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Sep 3;19(21):6209–6212. doi: 10.1016/j.bmcl.2009.08.092

Scheme 1.

Scheme 1

Synthesis of 8. Reagent, conditions and yields: a) concentrated HCl, NaNO2, ethyl 2-chloroacetoacetate, NaOAc, EtOH– H2O, 16 h, 72%; b) 4-methoxybenzoylacetonitrile, DIPEA, tert-BuOH, reflux, 16 h, 6%; c) aq-LiOH, THF, 65 °C, 4 h; d) DMF(cat), (COCl)2, DCM; e) 1-aminopiperidine, DIPEA, DCM, 2 h, 73%.