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Ki values for CB1 and CB2 receptors, selectivities for CB1 versus CB2 receptors and calculated lipophilicities.
 | ||||
|---|---|---|---|---|
| Ligand | CB1Ki (nM)a | CB2Ki (nM)a | CB1 versus CB2 selectivitya | cLogD7.4b |
| rimonabant | 1.38 ± 0.17 | 927 ± 66 | 672 ± 94 | 6.01 |
| 8 | 3.40 ± 0.43 | 548 ± 23 | 161 ± 47 | 4.14 |
Values represent mean ± SD of three determinations.
cLogD7.4 values were calculated using Advanced Chemistry Development (ACD) 9.2.
