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. Author manuscript; available in PMC: 2010 Aug 7.
Published in final edited form as: Cell. 2009 Aug 7;138(3):449–462. doi: 10.1016/j.cell.2009.05.035

Figure 6. Knockdown of Ngn3 prevents the Pax4-mediated β-cell hyperplasia.

Figure 6

(A-H) Infection of POE::Glucre animals using lentiviruses producing either an shRNA targeting Ngn3 transcripts (E-H - Xu et al., 2008) or producing a scrambled shRNA (based on the former; A-D). Two weeks post-infection, Ngn3 knockdown pancreata (at the indicated magnifications) display an efficient 61% diminution in Ngn3 production (Xu et al., 2008, A, E and Table S6), but also a 69% decrease in insulin- (B, F, D, H) or glucagon- (C, G) expressing cell numbers (Table S6) compared to scramble-infected counterparts.