Figure 1.

Effects of FTI (SCH56582) on the morphology of NRK and KNRK cells. NRK and KNRK cells were plated at the density of 5 × 10⁴ cells/well in a 4-well chamber slide (LAB-TEK) and, after 24 h, treated with DMSO (A and C) or with 20 μM SCH56582 (B and D). The phase–contrast images were captured at ×400 magnification 24 h after the FTI addition. (A) KNRK. (B) KNRK treated with 20 μM SCH56582. (C) NRK. (D) NRK treated with 20 μM SCH56582. At least three separate experiments were carried out with results similar to those shown here.